The La Paz Hospital has incorporated the “latest technology» in massive sequencing for the diagnosis and treatment of cancer and other genetically based diseases. These are two teams that are already in operation, one in the Pathological Anatomy Service and the other in the Genetics Service, the regional Executive explained in a statement.
This new generation NGS (Next Generation Sequencing) technique is used for solid tumors in adults and is performed by the Pathological Anatomy Service, which directs the doctor David Hardisson.
Allows simultaneous analysis of the main molecular alterations involved in this type of cancerand represents an important step in the advancement of precision or personalized medicine, essential for diagnosis, evaluation of prognosis and selection of targeted therapies in cancer patients.
Massive sequencing makes it possible, from tissue and/or somatic cell samples, to analyze the main molecular alterations involved in solid tumors. In this way, more precise data on the molecular profile of these tumors are provided. Until now, it had been carried out sequentially, using different molecular techniques for the individual analysis of each biomarker.
The information obtained helps the specialists of the Medical Oncology Service, directed by Dr. Jaime Feliuto design individualized therapeutic strategies for people with cancer.
More than 400 patients will benefit
A) Yes, more than 400 cancer patients from La Paz will be able to benefit each year from the incorporation of this new technique to the portfolio of services.
Likewise, massive sequencing also facilitates the selection of cancer patients for possible inclusion in clinical trials.
The system provides a computer program that helps interpret the results obtained and that locates open clinical trials, both national and international, increasing the therapeutic possibilities.
This technique implemented in the public University Hospital La Paz It comes to complement the determinations made by the Genetics Service for several years and that has positioned it as a “reference center at the national level”.
A service, directed by Dr. Sonia Rodríguez Bride, which has had a powerful Massive Sequencing Unit for almost a decade. This equipment, in addition to allowing exome analysis, which was already being carried out as part of the care activity, allows the complete study of the human genome.
Both the study of exome and the genome are positioned as the most promising techniques with the highest diagnostic performance for the resolution of cases of diseases of genetic origin.
In the public University Hospital La Paz For decades, patients with both minority diseases and major diseases with a great impact on the health of the population have been cared for. Since massive sequencing studies began, thousands of people have benefited from these new technologies.
The Mass Sequencing Unit has on its staff a team of laboratory technicians with highly specialized training in these technologies in continuous training to be able to incorporate improvements in daily practice. The service also has a Bioinformatics Unit that makes it possible to process and interpret the data generated in the massive sequencers.